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Changes on the properties of glycine receptors during neuronal development
 

Summary: Review
Changes on the properties of glycine receptors during
neuronal development
Luis G. Aguayoa,*, Brigitte van Zunderta
, Juan C. Tapiaa
,
Monica A. Carrascoa
, Francisco J. Alvarezb
a
Laboratory of Neurophysiology, Department of Physiology, University of Concepcion P.O. Box 160-C, ConcepciŽon, Chile
b
Department of Anatomy, Wright State University, Dayton, OH, USA
Accepted 11 June 2004
Available online 2 September 2004
Abstract
Glycine receptors (GlyRs) play a major role in the excitability of spinal cord and brain stem neurons. During development, several properties
of these receptors undergo significant changes resulting in major modifications of their physiological functions. For example, the receptor
structure switches from a monomeric a or heteromeric a2h in immature neurons to an a1h receptor type in mature neurons. Together with these
changes in receptor subunits, the postsynaptic cluster size increases with development. Parallel to these modifications, the apparent receptor
affinity to glycine and strychnine, as well as that of Zn2 +

  

Source: Alvarez, Francisco J. - Department of Neuroscience, Cell Biology, and Physiology, Wright State University

 

Collections: Biology and Medicine