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Nature Macmillan Publishers Ltd 1997 metabolic pathway. Not only will there
 

Summary: Nature Macmillan Publishers Ltd 1997
metabolic pathway. Not only will there
be a decrease in the pain-producing
prostaglandins(byinhibitionofcyclooxyge-
nase),buttherewillbeincreasedproduction
of pain-relieving lipoxygenase metabolites,
whichareactivatedbyopioids.
Vaughan et al. used brain slices contain-
ing the periaqueductal grey (PAG) -- a cen-
tralsiteinthemodulationofpainpathways4
.
OneofthemaineffectsofopioidsinthePAG
(and the measure used in this study) is the
presynaptic inhibition of GABA ( -amino-
butyric acid)-mediated synaptic currents5
.
Although opioid-mediated presynaptic
inhibition, particularly from GABA-releas-
ing terminals, is common in the central
nervous system, there is no consensus on the

  

Source: Avraham, Karen - Department of Human Genetics and Molecular Medicine, Tel Aviv University

 

Collections: Biology and Medicine