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Molecular Biology of the Cell Vol. 12, 22572274, August 2001

Summary: Molecular Biology of the Cell
Vol. 12, 22572274, August 2001
Cdc42-dependent Modulation of Tight Junctions and
Membrane Protein Traffic in Polarized Madin-Darby
Canine Kidney Cells
Raul Rojas,* Wily G. Ruiz,* Som-Ming Leung,* Tzuu-Shuh Jou,
Gerard Apodaca*
*Renal-Electrolyte Division of the Department of Medicine, Laboratory of Epithelial Biology, and
Department of Cell Biology and Physiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261;
Department of Internal Medicine, National Taiwan University Hospital, Taipei, 100 Taiwan
Submitted September 11, 2000; Revised May 10, 2001; Accepted May 15, 2001
Monitoring Editor: Suzanne R. Pfeffer
Polarized epithelial cells maintain the asymmetric composition of their apical and basolateral
membrane domains by at least two different processes. These include the regulated trafficking of
macromolecules from the biosynthetic and endocytic pathway to the appropriate membrane
domain and the ability of the tight junction to prevent free mixing of membrane domain-specific
proteins and lipids. Cdc42, a Rho family GTPase, is known to govern cellular polarity and
membrane traffic in several cell types. We examined whether this protein regulated tight junction


Source: Apodaca, Gerard - Departments of Medicine & Cell Biology and Physiology, University of Pittsburgh


Collections: Biology and Medicine