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Copyright 1998 by the Genetics Society of America Letter to the Editor

Summary: Copyright 1998 by the Genetics Society of America
Letter to the Editor
The Effect of Gene Conversion on Intralocus Associations
Peter Andolfatto* and Magnus Nordborg*,
*Committee on Genetics, Department of Ecology and Evolution, University of Chicago, Chicago, Illinois 60637 and

Department of Genetics, Lund University, Sošlvegatan 29, 223 62 Lund, Sweden
Manuscript received July 12, 1997
Accepted for publication November 24, 1997
SEVERAL predictions of the genomic pattern of nu- A crude model: It is intuitive that gene conversion
should increase the rate of exchange for closely linkedcleotide polymorphism include the local recombi-
nation rate, r, as a parameter. In typical population sites, but should have negligible effects for more distant
sites. Assume that over very short intervals, the probabil-genetic models, the parameter r, for two specified loci
(or sites), is properly defined as the probability that a ity of crossing-over increases linearly with d, the physi-
cal distance in base pairs between two sites. Thus therandomly selected gamete produced by a double het-
erozygote is a recombinant. In a given region, r can probability of producing a recombinant by crossing-over
equals d, where is the probability of a crossing-overbe measured directly through genetic crosses. This is
typically done by observing markers spaced several centi- event between two given sites per base pair per genera-
tion. We suggest that the following crude model de-morgans apart, in which case recombinants are pro-
duced almost exclusively by classical crossing-over. Over scribes the added effect of gene conversion events on


Source: Andolfatto, Peter - Department of Ecology and Evolutionary Biology, Princeton University


Collections: Biology and Medicine