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Summary: Nicotinic Receptors at
Neuromuscular Junction
Hadi Tajalli
Acetylcholine is synthesized from
AcetylCoA (acetyl coenzyme A) + choline (dietary nutrient)
· Acetylcholine is one of the first known neurotransmitter.
(Otto Loewi experiment 1921)
Neuromuscular Junction
Presynaptic side of NMJ
· Presynaptic side of NMJ
Active zone
· High concentration of synaptic
vesicles
· Dense bar (to line up the
vesicles)
Mitochondria to provide the energy
for
· Secretion
· Reuptake of vesicles
· Regulate the calcium in the
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