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Prefrontal Contributions to Executive Control: fMRI Evidence for Functional Distinctions within Lateral Prefrontal Cortex
 

Summary: Prefrontal Contributions to Executive Control: fMRI Evidence
for Functional Distinctions within Lateral Prefrontal Cortex
Anthony D. Wagner,*,
Anat Maril, Robert A. Bjork,§ and Daniel L. Schacter
*Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139; MGH­NMR
Center, Charlestown, Massachusetts 02129; Department of Psychology, Harvard University, Cambridge, Massachusetts 02138; and
§Department of Psychology, University of California at Los Angeles, Los Angeles, California 90095
Received February 11, 2001; published online October 24, 2001
The prefrontal cortex (PFC) plays a fundamental role
in internally guided behavior. Although it is generally
accepted that PFC subserves working memory and ex-
ecutive control operations, it remains unclear whether
the subregions within lateral PFC support distinct exec-
utive control processes. An event-related fMRI study
was implemented to test the hypothesis that ventrolat-
eral and dorsolateral PFC are functionally distinct, as
well as to assess whether functional specialization exists
within ventrolateral PFC. Participants performed two
executive control tasks that differed in the types of con-
trol processes required. During rote rehearsal, partici-

  

Source: Anat, Maril, - Departments of Psychology & Cognitive Science, Hebrew University of Jerusalem
Wagner, Anthony - Department of Psychology, Stanford University

 

Collections: Biology and Medicine