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Yeast 15, 573584 (1999) Regulated Expression of the Saccharomyces cerevisiae
 

Summary: YEAST
Yeast 15, 573584 (1999)
Regulated Expression of the Saccharomyces cerevisiae
Fre1p/Fre2p Fe/Cu Reductase Related Genes
ELENA GEORGATSOU1
AND DESPINA ALEXANDRAKI1,2
*
1
Foundation for Research and Technology-HELLAS, Institute of Molecular Biology and Biotechnology,
PO Box 1527, Heraklion 711 10 Crete, Greece
2
Department of Biology, University of Crete, PO Box 1527, Heraklion 711 10 Crete, Greece
The Saccharomyces cerevisiae genome contains nine open reading frames (ORFs)--YLR214w (FRE1), YKL220c
(FRE2), YOR381w, YNR060w, YOR384w, YLL051c, YOL152w, YGL160w and YLR047c--which, based on amino
acid sequence similarity, fall in the category of iron/copper reductase-related genes. FRE1 and FRE2 are the first
identified and studied genes of this family. They both encode for plasma membrane ferric/cupric reductases and their
expression is regulated by iron and copper availability, mediated by the transcription factors Aft1p and Mac1p,
respectively. We have studied the expression of the seven ORFs of unknown function by monitoring mRNA
accumulation under different growth conditions, namely, their response to iron and copper availability in the
medium, as well as the involvement of transcription factors Aft1p and Mac1p in their expression. A compilation of

  

Source: Alexandraki, Despina - Institute of Molecular Biology and Biotechnology, Foundation of Research and Technology, Hellas

 

Collections: Biology and Medicine; Biotechnology