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Synaptic Depression and the Temporal Response Characteristics of V1 Cells

Summary: Synaptic Depression and the Temporal Response Characteristics
of V1 Cells
Frances S. Chance, Sacha B. Nelson, and L. F. Abbott
Volen Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02254-9110
We explore the effects of short-term synaptic depression on the
temporal dynamics of V1 responses to visual images by con-
structing a model simple cell. Synaptic depression is modeled
on the basis of previous detailed fits to experimental data. A
component of synaptic depression operating in the range of
hundreds of milliseconds can account for a number of the
unique temporal characteristics of cortical neurons, including
the bandpass nature of frequency­response curves, increases
in response amplitude and in cutoff frequency for transient
stimuli, nonlinear temporal summation, and contrast-
dependent shifts in response phase. Synaptic depression also
provides a mechanism for generating the temporal phase shifts
needed to produce direction selectivity, and a model con-
structed along these lines matches both extracellular and in-
tracellular data. A slower component of depression can repro-
duce the effects of contrast adaptation.


Source: Abbott, Laurence - Center for Neurobiology and Behavior & Department of Physiology and Cellular Biophysics, Columbia University
Chance, Frances A. - Department of Neurobiology and Behavior, University of California, Irvine


Collections: Biology and Medicine