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Model-Based Factor Analysis of Dynamic Sequences of Cardiac Positron Emission Tomography
 

Summary: 1
Model-Based Factor Analysis of Dynamic Sequences of
Cardiac Positron Emission Tomography
1
Abstract Factor analysis has been pursued as a means to
decompose dynamic cardiac PET images into different tissue types
based on their unique temporal signatures. In this work we present
a kinetic model-based (MB) method that includes physiological
models of factor relationships within the decomposition process. A
gamma-variate model was used to describe the transport of 82
Rb in
arterial blood from the right to left ventricle, and a one-
compartment model to describe the exchange between blood and
myocardium. Simulations of canine and rat heart imaging were
performed to evaluate parameter estimation errors. Arterial blood
sampling and 11
CO blood pool imaging were used to evaluate factor
and structure accuracy. Variable infusion duration studies were
used to evaluate MB structure and global myocardial blood flow
(MBF) reproducibility. All results were compared with a previously

  

Source: Adler, Andy - Department of Systems and Computer Engineering, Carleton University

 

Collections: Computer Technologies and Information Sciences