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Copyright 2002 by the Genetics Society of America Genetic Analysis of Tissue Aging in Caenorhabditis elegans
 

Summary: Copyright 2002 by the Genetics Society of America
Genetic Analysis of Tissue Aging in Caenorhabditis elegans:
A Role for Heat-Shock Factor and Bacterial Proliferation
Delia Garigan,* Ao-Lin Hsu,* Andrew G. Fraser,
Ravi S. Kamath,
Julie Ahringer
and Cynthia Kenyon*,1
*Department of Biochemistry and Biophysics and Program in Neuroscience, University of California, San Francisco, California 94143-0448
and
Wellcome/CRC Institute, University of Cambridge, CB2 1QR Cambridge, United Kingdom
Manuscript received December 3, 2001
Accepted for publication April 11, 2002
ABSTRACT
The genetic analysis of life span has revealed many interesting genes and pathways; however, our
understanding of aging has been limited by the lack of a way to assay the aging process itself. Here we
show that the tissues of aging worms have a characteristic appearance that is easy to recognize and quantify
using Nomarski optics. We have used this assay to determine whether life-span mutations affect the rate of
aging, to identify animals that age more rapidly than normal, and to infer the cause of death in C. elegans.
Mutations that reduce insulin/IGF-1 signaling double the life span of C. elegans, and we find that tissue
decline is slowed in these mutants. Thus this endocrine system appears to influence the rate at which

  

Source: Ahringe, Julie - Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge

 

Collections: Biology and Medicine