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Nucleic Acids Research, 2008, 112 doi:10.1093/nar/gkn024

Summary: Nucleic Acids Research, 2008, 112
Alternative splicing of Alu exons--two arms are
better than one
Nurit Gal-Mark, Schraga Schwartz and Gil Ast*
Department of Human Genetics and Molecular Biochemistry, Sackler Faculty of Medicine, Tel Aviv University,
Ramat Aviv 69978, Israel
Received September 24, 2007; Revised and Accepted January 16, 2008
Alus, primate-specific retroelements, are the most
abundant repetitive elements in the human genome.
They are composed of two related but distinct
monomers, left and right arms. Intronic Alu ele-
ments may acquire mutations that generate func-
tional splice sites, a process called exonization.
Most exonizations occur in right arms of antisense
Alu elements, and are alternatively spliced. Here we
show that without the left arm, exonization of the
right arm shifts from alternative to constitutive
splicing. This eliminates the evolutionary conserved


Source: Ast, Gil - Department of Molecular Genetics and Biochemistry, Tel Aviv University


Collections: Biology and Medicine