Summary: Genet. Res., Camb. (2001), 77, pp. 1­8. With 3 figures. Printed in the United Kingdom # 2001 Cambridge University Press 1
In ersion polymorphisms and nucleotide ariability in
Drosophila
PETER ANDOLFATTO"*, FRANTZ DEPAULIS" AND ARCADIO NAVARRO"
1
Institute of Cell, Animal & Population Biology, Uni ersity of Edinburgh, Edinburgh, EH9 3JT, UK
Introduction
Population genetic models of molecular variation
usually assume that most genetic variability is neutral
or nearly so (Kimura, 1983). However, even if most
variability is neutral, patterns of polymorphism may
be indirectly shaped by natural selection (Gillespie,
1997). Indeed, theoretical studies show that neutral
variability linked to selected sites may be influenced
by different types of natural selection, including
balancing selection (Strobeck, 1983; Hudson &
Kaplan, 1988), Hill-Robertson interference (Hill &
Robertson, 1966) or directional selection (Maynard
Smith & Haigh, 1974; Charlesworth et al., 1993;
Gillespie, 1997). In all these models of evolution, the

Source: Andolfatto, Peter - Department of Ecology and Evolutionary Biology, Princeton University

Collections: Biology and Medicine