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Summary: Hypersusceptibility of cystic fibrosis mice to chronic
Pseudomonas aeruginosa oropharyngeal
colonization and lung infection
Fadie T. Coleman*, Simone Mueschenborn*, Gloria Meluleni*, Christopher Ray*, Vincent J. Carey*, Sara O. Vargas
,
Carolyn L. Cannon*
, Frederick M. Ausubel§
, and Gerald B. Pier*¶
*Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Division of Respiratory Diseases, Department of Pathology,
Children's Hospital, and §Department of Genetics, Harvard Medical School, Boston, MA 02115
Contributed by Frederick M. Ausubel, December 24, 2002
No transgenic cystic fibrosis (CF) mouse model developed to date
mimics the major clinical phenotype found in humans with CF,
chronic Pseudomonas aeruginosa lung infection. In a transgenic CF
transmembrane conductance regulator (cftr) mouse colony, we
found WT, heterozygous, and homozygous CF mice housed in the
same cage became chronically colonized in the oropharynx with
environmental P. aeruginosa when the bacterium was present in
drinking water. Elimination of P. aeruginosa from drinking water
resulted in clearance in most WT and CF heterozygous, but not
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