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ARTICLE doi:10.1038/nature10236 Structure of the human histamine H1

Summary: ARTICLE doi:10.1038/nature10236
Structure of the human histamine H1
receptor complex with doxepin
Tatsuro Shimamura1,2,3
*, Mitsunori Shiroishi1,2,4
*, Simone Weyand1,5,6
, HirokazuTsujimoto1,2
, GraemeWinter6
, VsevolodKatritch7
Ruben Abagyan7
, Vadim Cherezov3
, Wei Liu3
, Gye Won Han3
, Takuya Kobayashi1,2
, Raymond C. Stevens3
& So Iwata1,2,5,6,8
The biogenic amine histamine is an important pharmacological mediator involved in pathophysiological processes such as
allergies and inflammations. Histamine H1 receptor (H1R) antagonists arevery effective drugs alleviating the symptoms of
allergic reactions. Here we show the crystal structure of the H1R complex with doxepin, a first-generation H1R antagonist.


Source: Abagyan, Ruben - School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego


Collections: Biology and Medicine