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The worm has turned microbial virulence modeled in

Summary: The worm has turned microbial
virulence modeled in
Caenorhabditis elegans
Costi D. Sifri1
, Jakob Begun2
and Frederick M. Ausubel2
Division of Infectious Diseases and International Health, University of Virginia Health System, MR4, Charlottesville, VA 22908, USA
Department of Molecular Biology, Massachusetts General Hospital, Wellman 10, 50 Blossom Street, Boston, MA 02114, USA
The nematode Caenorhabditis elegans is emerging as a
facile and economical model host for the study of evolu-
tionarily conserved mechanisms of microbial patho-
genesis and innate immunity. A rapidly growing number
of human and animal microbial pathogens have been
shown to injure and kill nematodes. In many cases,
microbial genes known to be important for full virulence
in mammalian models have been shown to be similarly
required for maximum pathogenicity in nematodes.
C. elegans has been used in mutation-based screening


Source: Ausubel, Frederick M. - Department of Genetics, Harvard University


Collections: Biology and Medicine