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Chronoamperometry To Determine Differential Reductions in Uptake in Brain Synaptosomes from
 

Summary: Chronoamperometry To Determine Differential
Reductions in Uptake in Brain Synaptosomes from
Serotonin Transporter Knockout Mice
Xiomara A. Perez and Anne M. Andrews*,,
Department of Chemistry and Huck Institutes of the Life Sciences, Pennsylvania State University,
University Park, Pennsylvania 16802-4615
The serotonin transporter (SERT) is a neuronal plasma
membrane protein whose primary function is to take up
the neurotransmitter serotonin from the extracellular
space, thereby controlling the spatial and temporal as-
pects of serotonergic signaling in the brain. In humans, a
commonly expressed genetic variant of the serotonin
transporter gene results in 40% reductions in SERT
expression that have been linked to increases in anxiety-
related personality traits and susceptibility to stress-
associated depression. Mice have been engineered to
express similar reductions in SERT expression to inves-
tigate transporter-mediated control of serotonin neu-
rotransmission and behavior. We employed carbon fiber
microelectrode voltammetry (chronoamperometry) to ex-

  

Source: Andrews, Anne M. - Huck Institutes of the Life Sciences, Pennsylvania State University

 

Collections: Biology and Medicine