Summary: DIPLOMA / MASTER THESIS in Tumor Cell Targeting
One major cause of human cancers is the upregulation of
oncogenes. We developed interfering peptides (iPEP) which block
these tumorigenic proteins to reconstitute the physiological state of
the cell. For applications, the discrimination between tumor cells
and healthy cells is a main issue. The specific targeting of tumor
cells is the main goal of this diploma or master thesis. Fusion
proteins of peptides with natural receptor ligands or antibodies
targeting tumor receptors will be generated in order to administer
the interfering peptides in a highly specific way to tumor cells.
Different techniques from molecular biology (cloning), protein
biochemistry (protein expression and purification) as well as cell
biology (microscopy, proliferation and toxicity assays, cytometry)
will be applied.
Our team currently comprises seven members from four different countries. The lab
with state-of-the-art equipment is promoted by the German Excellence Initiative with
the excellence cluster bioss (biological signaling studies), the Freiburg Institute for
Advanced Studies (FRIAS) as well as the new collaborative research center 850
"Control of Cell Motility in Morphogenesis, Cancer Invasion and Metastasis.