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Summary: Article
The Rockefeller University Press $30.00
J. Exp. Med. Vol. 207 No. 13 2869-2881
www.jem.org/cgi/doi/10.1084/jem.20100090
2869
HIV infection is characterized by the progres-
sive depletion of CD4T helper cells, eventually
leading to AIDS and the onset of various op-
portunistic diseases. Highly active antiretroviral
therapy interrupts HIV replication and leads to
increases in CD4 T cell numbers and function,
with associated clearance of many opportunis-
tic infections. Data indicate that ongoing viral
replication within CD4 T cells is among the
most important parameters driving the massive,
systemic depletion of memory CD4 T cells
during acute immunodeficiency virus infection
(Li et al., 2005; Mattapallil et al., 2005) and the
CORRESPONDENCE
Christof Geldmacher:
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