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Norbin is an endogenous regulator of metabotropic glutamate receptor 5 signaling
 

Summary: Norbin is an endogenous regulator of metabotropic glutamate
receptor 5 signaling
Hong Wang1, Linda Westin2, Yi Nong1, Shari Birnbaum3, Jacob Bendor1, Hjalmar
Brismar2,4, Eric Nestler5, Anita Aperia2, Marc Flajolet1,*, and Paul Greengard1
1Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York,
NY10065, USA
2Department of Woman and Child Health, Karolinska Institutet, Astrid Lindgren Children's Hospital
Q2:09, S-171 76 Stockholm, Sweden
3Departments of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390,
USA
4Department of Applied Physics, Cell Physics, Royal Institute of Technology, S-106 91 Stockholm,
Sweden
5Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, NY10029, USA
SUMMARY
Metabotropic glutamate receptor 5 (mGluR5) is highly expressed in the mammalian central nervous
system (CNS). It is involved in multiple physiological functions and is a target for treatment of various
CNS disorders, including schizophrenia. We report that Norbin, a neuron-specific protein, physically
interacts with mGluR5 in vivo, increases the cell surface localization of the receptor and positively
regulates mGluR5 signaling. Genetic deletion of Norbin attenuates mGluR5-dependent stable
changes in synaptic function measured as long-term depression or long-term potentiation of synaptic

  

Source: Alford, Simon - Department of Biological Sciences, University of Illinois at Chicago

 

Collections: Biology and Medicine