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Analysis of SAGE Results with Combined Learning Techniques
 

Summary: Analysis of SAGE Results with Combined
Learning Techniques
Hsuan-Tien Lin and Ling Li
Learning Systems Group, California Institute of Technology, USA
htlin@caltech.edu, ling@caltech.edu
Abstract. Serial analysis of gene expression (SAGE) experiments could
provide us the expression level of thousands of genes in a biological
sample. However, the number of available samples is relatively small.
Such undersampled problem needs to be carefully analyzed from a ma-
chine learning perspective. In this paper, we combine several state-of-the-
art techniques for classification, feature selection, and error estimation,
and evaluate the performance of the combined techniques on the SAGE
dataset. Our results show that a novel algorithm, support vector ma-
chine with the stump kernel, performs well on the SAGE dataset both
for building an accurate classifier, and for selecting relevant features.
1 Introduction
Serial analysis of gene expression (SAGE) experiments could provide us an enor-
mous amount of information on the expression level of different genes in some
cell populations. The expression level is evaluated by counting the occurrences
of the SAGE tags that can identify an unique transcript [1].

  

Source: Abu-Mostafa, Yaser S. - Department of Mechanical Engineering & Computer Science Department, California Institute of Technology

 

Collections: Computer Technologies and Information Sciences