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Summary: Rapid Two-Dimensional Inverse Detected
Heteronuclear Correlation Experiments with <100
nmol Samples with Solenoidal Microcoil NMR
Probes
Raju Subramanian,
Jonathan V. Sweedler,,
and
Andrew G. Webb*,,§
Department of Chemistry, Department of Electrical and
Computer Engineering, Beckman Institute for AdVanced
Science and Technology, UniVersity of Illinois at
Urbana-Champaign, 405 North Mathews AVenue
Urbana, Illinois 61801
ReceiVed December 10, 1998
ReVised Manuscript ReceiVed February 3, 1999
Nuclear magnetic resonance (NMR) is a powerful analytical
tool capable of determining three-dimensional structures for
molecules as complicated as large proteins. It suffers, however,
from an inherently low sensitivity compared to almost all other
analytical methods. Studies of mass-limited samples such as minor
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