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Human brain mechanisms of pain perception and regulation in health and disease
 

Summary: Human brain mechanisms of pain perception and
regulation in health and disease
A. Vania Apkarian a,*, M. Catherine Bushnell b
, Rolf-Detlef Treede c
, Jon-Kar Zubieta d
a
Department of Physiology, Northwestern University Medical School, 303 E. Chicago Avenue, Ward 5-003, Chicago, IL 60611, USA
b
Department of Anesthesia, McGill University, Montreal, Canada
c
Institute of Physiology and Pathophysiology, Johannes Gutenberg University, Mainz, Germany
d
Department of Psychiatry and Radiology, University of Michigan, Ann Arbor, MI, USA
Received 31 August 2004; accepted 2 November 2004
Available online 21 January 2005
Abstract
Context: The perception of pain due to an acute injury or in clinical pain states undergoes substantial processing at supraspinal
levels. Supraspinal, brain mechanisms are increasingly recognized as playing a major role in the representation and modulation of
pain experience. These neural mechanisms may then contribute to interindividual variations and disabilities associated with chronic
pain conditions.

  

Source: Apkarian, A. Vania - Department of Physiology, Northwestern University

 

Collections: Biology and Medicine