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Am. J. Hum. Genet. 68:13021307, 2001 Broad and Narrow Heritabilities of Quantitative Traits
 

Summary: Am. J. Hum. Genet. 68:13021307, 2001
1302
Report
Broad and Narrow Heritabilities of Quantitative Traits
in a Founder Population
Mark Abney,1,2
Mary Sara McPeek,1,2
and Carole Ober1
Departments of 1
Human Genetics and 2
Statistics, University of Chicago, Chicago
Estimation of the components of variance for a quantitative trait allows one to evaluate both the degree to which
genetics influences the trait and the trait's underlying genetic architecture. For particular traits, the estimates also
may have implications for discriminating between potential models of selection and for choosing an appropriate
model for linkage analysis. Using a recently developed method, we estimate the additive and dominance components
of variance--or, equivalently, the narrow and broad sense heritabilities--of several traits in the Hutterites, a founder
population with extensive genealogical records. As a result of inbreeding and because Hutterite individuals are
typically related through multiple lines of descent, we expect that power to detect dominance variance will be
increased relative to that in outbred studies. Furthermore, the communal lifestyle of the Hutterites allows us to
evaluate the genetic influences in a relatively homogeneous environment. Four phenotypes had a significant dom-

  

Source: Abney, Mark - Department of Human Genetics, University of Chicago

 

Collections: Computer Technologies and Information Sciences; Biology and Medicine