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Background gamma rhythmicity and attention in cortical local circuits: A computational study
 

Summary: Background gamma rhythmicity and attention
in cortical local circuits: A computational study
Christoph Bo¨ rgers*
, Steven Epstein§
, and Nancy J. Kopell§
*Department of Mathematics, Tufts University, Medford, MA 02155; and §Department of Mathematics and Center for Biodynamics, Boston University,
Boston, MA 02215
Contributed by Nancy J. Kopell, March 22, 2005
We describe a simple computational model, based on generic
features of cortical local circuits, that links cholinergic neuromodu-
lation, gamma rhythmicity, and attentional selection. We propose
that cholinergic modulation, by reducing adaptation currents in
principal cells, induces a transition from asynchronous spontane-
ous activity to a ``background'' gamma rhythm (resembling the
persistent gamma rhythms evoked in vitro by cholinergic agonists)
in which individual principal cells participate infrequently and
irregularly. We suggest that such rhythms accompany states of
preparatory attention or vigilance and report simulations demon-
strating that their presence can amplify stimulus-specific responses
and enhance stimulus competition within a local circuit.

  

Source: Andrzejak, Ralph Gregor - Departament de Tecnologia, Universitat Pompeu Fabra
Kopell, Nancy - Center for BioDynamics, Boston University

 

Collections: Biology and Medicine; Computer Technologies and Information Sciences