Summary: © The Rockefeller University Press, 0021-9525/97/12/1455/10 $2.00
The Journal of Cell Biology, Volume 139, Number 6, December 15, 1997 1455­1464
http://www.jcb.org 1455
Activation of a Retroviral Membrane Fusion
Protein: Soluble Receptor-induced Liposome
Binding of the ALSV Envelope Glycoprotein
Lorraine D. Hernandez,*
Reuben J. Peters,§
Sue E. Delos,* John A.T. Young, David A. Agard,§
and Judith M. White*
*Department of Cell Biology, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908;
Department of
Biochemistry and Biophysics, §
Howard Hughes Medical Institute, University of California, San Francisco, California 94143; and
Department of Microbiology and Molecular Genetics, Harvard Medical School, Cambridge, Massachusetts 02138
Abstract. It is not known how membrane fusion pro-
teins that function at neutral pH, for example the hu-
man immunodeficiency virus envelope (Env) glycopro-
tein and intracellular fusion machines, are activated for
target bilayer binding. We have addressed this question

Source: Agard, David - Department of Biochemistry and Biophysics, University of California at San Francisco

Collections: Biotechnology; Biology and Medicine