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Summary: In Situ Preparation of
-D-1-O-Hydroxylamino Carbohydrate
Polymers Mediated by Galactose
Oxidase
Peter R. Andreana, Wenhua Xie, Huai N. Cheng, Lei Qiao, Dennis J. Murphy,
Qu-Ming Gu, and Peng G. Wang*
Department of Chemistry, Wayne State UniVersity, Detroit, Michigan 48202-3489
pwang@chem.wayne.edu
Received March 7, 2002
ABSTRACT
Galactose oxidase produced a C-6 aldehyde in various terminal-containing galactose hydroxylamines for the simultaneous in situ generation
of an A-B type condensation for the construction of unique oxime polymers. Molecular weights of the corresponding polymers were determined
to be in the range of 4200-8900 g/mol, respectively. This indicates that approximately 20-25 sugar units were incorporated in these unique
polymers.
Synthetic or modified natural carbohydrate polymers have
a wide variety of practical applications including hydrogels,1
adsorbents,2
biorecognition agents,3
and glycoconjugate
assemblies.4 Carbohydrates conjugated to a variety of materi-
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