Summary: Genome Biology 2008, 9:R70
Open Access2008Paulet al.Volume 9, Issue 4, Article R70Research
Molecular signature of hypersaline adaptation: insights from
genome and proteome composition of halophilic prokaryotes
Sandip Paul*, Sumit K Bag*, Sabyasachi Das, Eric T Harvill and
Addresses: *Bioinformatics Center, Indian Institute of Chemical Biology, 4, Raja SC Mullick Road, Kolkata - 700 032, India. Department of
Biology, The Pennsylvania State University, Mueller Lab, University Park, PA 16802, USA. Department of Veterinary and Biomedical Sciences,
The Pennsylvania State University, University Park, PA 16802, USA. §Structural Biology and Bioinformatics Division, Indian Institute of
Chemical Biology, 4, Raja SC Mullick Road, Kolkata - 700 032, India.
Correspondence: Chitra Dutta. Email: firstname.lastname@example.org
© 2008 Paul et al.; licensee BioMed Central Ltd.
This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which
permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Molecular signatures of halophilic prokaryotes
A comparative genomic and proteomic study of halophilic and non-halophilic prokaryotes identifies specific genomic and proteomicfeatures typical of halophilic species that are independent from genomic GC-content and taxonomic position.
Background: Halophilic prokaryotes are adapted to thrive in extreme conditions of salinity.
Identification and analysis of distinct macromolecular characteristics of halophiles provide insight
into the factors responsible for their adaptation to high-salt environments. The current report
presents an extensive and systematic comparative analysis of genome and proteome composition