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2026 Current Pharmaceutical Design, 2010, 16, 2026-2032 1381-6128/10 $55.00+.00 2010 Bentham Science Publishers Ltd.

Summary: 2026 Current Pharmaceutical Design, 2010, 16, 2026-2032
1381-6128/10 $55.00+.00 2010 Bentham Science Publishers Ltd.
Dopaminergic Modulation of Cognitive Control: Distinct Roles for the Prefrontal
Cortex and the Basal Ganglia
Martine van Schouwenburg1,2,
*, Esther Aarts1,2
and Roshan Cools1,2
Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging,
Kapittelweg 29, 6525 EN, Nijmegen, The Netherlands, 2
Radboud University Nijmegen Medical Centre, Department of Psychiatry,
Reinier Postlaan 10, 6525 GN, Nijmegen, The Netherlands
Abstract: Evidence from psychopharmacological functional neuroimaging begins to elucidate the neurochemical mechanisms of
cognitive control. Here the role of dopamine in two subcomponent processes of cognitive control is discussed: the active maintenance
and the flexible updating of goal-relevant representations. A range of studies have highlighted a role for the prefrontal cortex (pFC) and
its modulation by dopamine in the active maintenance of distractor-resistant goal-relevant representations. This work suggests that
dopamine might modulate top-down signals from the pFC, thereby increasing the activity of posterior cortical regions that process goal-
relevant representations and rendering them distractor-resistant. Conversely, other studies highlight a role for dopamine in the basal
ganglia in cognitive switching, which might reflect a modulation of the selective gating of cortical cognitive and motor programs. We
present a working hypothesis that integrates these two disparate literatures and states that the flexible adaptation of current goal-relevant


Source: Aarts, Esther - Helen Wills Neuroscience Institute, University of California at Berkeley


Collections: Biology and Medicine