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Polak et al. BMC Evolutionary Biology 2010, 10:187 http://www.biomedcentral.com/1471-2148/10/187
 

Summary: Polak et al. BMC Evolutionary Biology 2010, 10:187
http://www.biomedcentral.com/1471-2148/10/187
Open AccessRESEARCH ARTICLE
© 2010 Polak et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons
Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in
any medium, provided the original work is properly cited.
Research article
The evolution of transcription-associated biases of
mutations across vertebrates
Paz Polak*1, Robert Querfurth2 and Peter F Arndt1
Abstract
Background: The interplay between transcription and mutational processes can lead to particular mutation patterns
in transcribed regions of the genome. Transcription introduces several biases in mutational patterns; in particular it
invokes strand specific mutations. In order to understand the forces that have shaped transcripts during evolution, one
has to study mutation patterns associated with transcription across animals.
Results: Using multiple alignments of related species we estimated the regional single-nucleotide substitution
patterns along genes in four vertebrate taxa: primates, rodents, laurasiatheria and bony fishes. Our analysis is focused
on intronic and intergenic regions and reveals differences in the patterns of substitution asymmetries between
mammals and fishes. In mammals, the levels of asymmetries are stronger for genes starting within CpG islands than in
genes lacking this property. In contrast to all other species analyzed, we found a mutational pressure in dog and

  

Source: Arndt, Peter - Max-Planck-Institut für molekulare Genetik
Spang, Rainer - Computational Molecular Biology Group, Max-Planck-Institut für molekulare Genetik

 

Collections: Biology and Medicine; Biotechnology; Computer Technologies and Information Sciences; Physics