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A number of different classes of segmental interneurones serve to control motoneurone excitability. One form of
 

Summary: A number of different classes of segmental interneurones
serve to control motoneurone excitability. One form of
postsynaptic inhibition, recurrent inhibition, has been
intensively studied over the years and is known to be
mediated by Renshaw cells (Eccles et al. 1954). These
interneurones use glycine and¤or GABA as their neuro-
transmitter (Cullheim & Kellerth, 1981; Fyffe, 1991a;
Schneider & Fyffe, 1992), and make contact predominantly
on the dendrites of their target motoneurones (Fyffe, 1991b).
Although the role of recurrent inhibition in motor control is
still not well defined (see e.g. Binder et al. 1996), it remains
important to understand how Renshaw cells themselves
might be regulated. Recent work suggests that Renshaw
cells are subject to strong glycinergic inhibitory inputs
distributed over their cell bodies and proximal dendrites
(Alvarez et al. 1997). In addition, a number of lines of
evidence point to the presence of a powerful cholinergic
input to Renshaw cells, a significant proportion of which is
probably mediated by postsynaptic nicotinic acetylcholine
receptors. The most prominent cholinergic input comes via

  

Source: Alvarez, Francisco J. - Department of Neuroscience, Cell Biology, and Physiology, Wright State University

 

Collections: Biology and Medicine