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Dynamics of Prestressed Semiflexible Polymer Chains as a Model of Cell Rheology Noah Rosenblatt,1
 

Summary: Dynamics of Prestressed Semiflexible Polymer Chains as a Model of Cell Rheology
Noah Rosenblatt,1
Adriano M. Alencar,2
Arnab Majumdar,1,3
Be´la Suki,1
and Dimitrije Stamenovic´1,*
1
Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, Massachusetts 02215, USA
2
Physiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
3
Department of Physics, Boston University, Boston, Massachusetts 02215, USA
(Received 10 May 2006; published 16 October 2006)
We report on a model of a prestressed nonlinear semiflexible polymer chain that links thermally driven
dynamics to the creep behavior of living cells. Numerical simulations show that the chain's creep follows
a power law with an exponent that decreases with increasing prestress. This is related to the propagation of
free energy through the chain in response to stretching, where the propagation speed is regulated by the
prestress via the chain's nonlinear elasticity. These results indicate that the main aspects of cell rheology
are consistent with the dynamics of single polymer chains under tension.
DOI: 10.1103/PhysRevLett.97.168101 PACS numbers: 87.15.Rn, 87.15.ÿv, 83.80.Lz, 83.85.Vb

  

Source: Alencar, Adriano Mesquita - Departamento de Física Geral, Universidade de São Paulo

 

Collections: Physics