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Synaptic Democracy in Active Dendrites Clifton C. Rumsey1
 

Summary: Synaptic Democracy in Active Dendrites
Clifton C. Rumsey1
and L. F. Abbott2
1
Center for Learning and Memory, The University of Texas at Austin, Austin, Texas; and 2
Center for Neurobiology and Behavior,
Department of Physiology and Cellular Biophysics, Columbia University College of Physicians and Surgeons, New York, New York
Submitted 13 February 2006; accepted in final form 4 July 2006
Rumsey, Clifton C. and L. F. Abbott. Synaptic democracy in active
dendrites. J Neurophysiol 96: 23072318, 2006. First published July
12, 2006; doi:10.1152/jn.00149.2006. Given the extensive attenuation
that can occur along dendritic cables, location within the dendritic tree
might appear to be a dominant factor in determining the impact of a
synapse on the postsynaptic response. By this reasoning, distal syn-
apses should have a smaller effect than proximal ones. However,
experimental evidence from several types of neurons, such as CA1
pyramidal cells, indicates that a compensatory strengthening of syn-
apses counteracts the effect of location on synaptic efficacy. A form
of spike-timing-dependent plasticity (STDP), called anti-STDP, com-
bined with non-Hebbian activity-dependent plasticity can account for

  

Source: Abbott, Laurence - Center for Neurobiology and Behavior & Department of Physiology and Cellular Biophysics, Columbia University

 

Collections: Biology and Medicine