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2006 Nature Publishing Group Sexual reproduction selects for robustness and
 

Summary:  2006 Nature Publishing Group
Sexual reproduction selects for robustness and
negative epistasis in artificial gene networks
Ricardo B. R. Azevedo1
, Rolf Lohaus1
, Suraj Srinivasan1
, Kristen K. Dang2
& Christina L. Burch3
The mutational deterministic hypothesis for the origin and
maintenance of sexual reproduction posits that sex enhances the
ability of natural selection to purge deleterious mutations after
recombination brings them together into single genomes1
. This
explanation requires negative epistasis, a type of genetic inter-
action where mutations are more harmful in combination than
expected from their separate effects. The conceptual appeal of the
mutational deterministic hypothesis has been offset by our
inability to identify the mechanistic and evolutionary bases of
negative epistasis. Here we show that negative epistasis can evolve
as a consequence of sexual reproduction itself. Using an artificial

  

Source: Azevedo, Ricardo - Department of Biology and Biochemistry, University of Houston

 

Collections: Biology and Medicine; Environmental Sciences and Ecology