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COBIOT-866; NO. OF PAGES 9 Please cite this article in press as: Jung ST, et al. Cytochrome P450: taming a wild type enzyme, Curr Opin Biotechnol (2011), doi:10.1016/j.copbio.2011.02.008
 

Summary: COBIOT-866; NO. OF PAGES 9
Please cite this article in press as: Jung ST, et al. Cytochrome P450: taming a wild type enzyme, Curr Opin Biotechnol (2011), doi:10.1016/j.copbio.2011.02.008
Available online at www.sciencedirect.com
Cytochrome P450: taming a wild type enzyme
Sang Taek Jung1,a
, Ryan Lauchli1,a
and Frances H Arnold1,2
Protein engineering of cytochrome P450 monooxygenases
(P450s) has been very successful in generating valuable non-
natural activities and properties, allowing these powerful
catalysts to be used for the synthesis of drug metabolites and in
biosynthetic pathways for the production of precursors of
artemisinin and paclitaxel. Collected experience indicates that
the P450s are highly `evolvable' they are particularly robust to
mutation in their active sites and readily accept new substrates
and exhibit new selectivities. Their ability to adapt to new
challenges upon mutation may reflect the nonpolar nature of
their active sites as well as their high degree of conformational
variability.
Addresses

  

Source: Arnold, Frances H. - Division of Chemistry and Chemical Engineering, California Institute of Technology

 

Collections: Chemistry; Biology and Medicine