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Molecular Psychiatry (2000) 5, 482488 2000 Macmillan Publishers Ltd All rights reserved 1359-4184/00 $15.00
 

Summary: Molecular Psychiatry (2000) 5, 482488
2000 Macmillan Publishers Ltd All rights reserved 1359-4184/00 $15.00
www.nature.com/mp
IMMEDIATE COMMUNICATION
Anxiety in healthy humans is associated with orbital
frontal chemistry
ID Grachev1,2
and AV Apkarian1,2
1
Department of Neurosurgery; 2
Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse,
New York 13210, USA
The present study examines relationships between regional brain chemistry (as identified by
localized in vivo three-dimensional single-voxel proton magnetic resonance spectroscopy (1
H-
MRS) and anxiety (as measured by the State-Trait Anxiety Inventory) in 16 healthy subjects.
The relative concentrations of N-Acetyl aspartate, choline, glutamate, glutamine, -aminobu-
tyric acid, inositol, glucose and lactate were measured relative to creatine within six 8-cm3
brain voxels localized to: thalamus, cingulate, insula, sensorimotor, dorsolateral prefrontal,
and orbital frontal cortices (OFC) in the left hemisphere. Analysis of variance, across brain

  

Source: Apkarian, A. Vania - Department of Physiology, Northwestern University

 

Collections: Biology and Medicine