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Chemotherapy might be the gold-standard treatment for the majority

Summary: Chemotherapy might be the gold-
standard treatment for the majority
of cancers but how much do we really
know about what happens inside
a cell once a drug has been added?
"Not enough," argue Ariel Cohen and
colleagues, who assert that a clearer
understanding of protein dynamics
in response to drug treatment might
shed light not only on how drugs
function, but also on why apparently
identical cells respond differently
following treatment. Guided by this
philosophy, the team from Uri Alon's
laboratory has recently set up an
elegant system allowing high tempo-
ral resolution of individual proteins
following drug treatment.
Using the H1299 human lung can-
cer cell line, the authors constructed


Source: Alon, Uri - Departments of Molecular Cell Biology & Physics of Complex Systems, Weizmann Institute of Science


Collections: Biology and Medicine