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Summary: Gene expression dynamics in the macrophage
exhibit criticality
Matti Nykter*
, Nathan D. Price
, Maximino Aldana
, Stephen A. Ramsey
, Stuart A. Kauffman§
, Leroy E. Hood¶
,
Olli Yli-Harja*, and Ilya Shmulevich¶
*Institute of Signal Processing, Tampere University of Technology, 33101 Tampere, Finland; Institute for Systems Biology, Seattle, WA 98103; Center of
Physical Sciences, National Autonomous University of Mexico, C.P. 62210, Cuernavaca, Morelos, Mexico; and §Institute for Biocomplexity and Informatics,
University of Calgary, Calgary, AB, Canada T2N 1NF
Contributed by Leroy E. Hood, December 14, 2007 (sent for review October 20, 2007)
Cells are dynamical systems of biomolecular interactions that
process information from their environment to mount diverse yet
specific responses. A key property of many self-organized systems
is that of criticality: a state of a system in which, on average,
perturbations are neither dampened nor amplified, but are prop-
agated over long temporal or spatial scales. Criticality enables the
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