Summary: TOR Signaling Pathway
for Nutrient-Regulated
Transcription Factors
Kyung Dae Ko
Outline
TOR
definition, domain organization and function
Hypotheses for the experiment
Procedures
Analysis of results
Summary
Future work
What is TOR?
The Target protein Of Rapamycin
Ser/thr protein kinase
Two distinct protein complexes
TORC1 and TORC2
Domain Organization in TOR
Kinase : phosphorylates serine and threonine
HEAT : mediates protein-protein interaction