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Plasmodium ookinetes coopt mammalian plasminogen to invade the mosquito midgut

Summary: Plasmodium ookinetes coopt mammalian plasminogen
to invade the mosquito midgut
Anil K. Ghosha
, Isabelle Coppensa
, Henrik Gårdsvollb
, Michael Plougb
, and Marcelo Jacobs-Lorenaa,1
Department of Molecular Microbiology and Immunology, Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD
21205; and b
Finsen Laboratory, Rigshospitalet, Copenhagen Biocenter, 2200 Copenhagen N, Denmark
Edited* by Peter Agre, Johns Hopkins Malaria Research Institute, Baltimore, MD, and approved August 30, 2011 (received for review March 6, 2011)
Ookinete invasion of the mosquito midgut is an essential step for
the development of the malaria parasite in the mosquito. Invasion
involves recognition between a presumed mosquito midgut re-
ceptor and an ookinete ligand. Here, we show that enolase lines the
ookinete surface. An antienolase antibody inhibits oocyst develop-
ment of both Plasmodium berghei and Plasmodium falciparum, sug-
gesting that enolase may act as an invasion ligand. Importantly, we
demonstrate that surface enolase captures plasminogen from the


Source: Arnold, Jonathan - Nanoscale Science and Engineering Center & Department of Genetics, University of Georgia


Collections: Biotechnology