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THEJOURNALOFCELLBIOLOGY JCB: ARTICLE
 

Summary: THEJOURNALOFCELLBIOLOGY
JCB: ARTICLE
The Rockefeller University Press $15.00
The Journal of Cell Biology, Vol. 176, No. 3, January 29, 2007 343353
http://www.jcb.org/cgi/doi/10.1083/jcb.200606023
JCB 343
Introduction
Tight junctions, adherens junctions (AJs), and desmosomes
promote adhesion between epithelial cells, initiate the assembly
of the mechanical cytoskeleton linkage, and facilitate the for-
mation of a polarized epithelial monolayer (Gumbiner, 1996).
AJs initiate these processes and are essential for morphogene-
sis, wound healing, and the retention of cell polarity and tissue
integrity (Perez-Moreno et al., 2003). In epithelia, AJ formation
is mediated by the calcium-dependent homophilic binding of
E-cadherin molecules on neighboring cells (Gumbiner, 1996).
These interactions link adjacent cells and promote the nucle-
ation of a cytoplasmic protein complex consisting of p120-, -,
and -catenins, which bridges E-cadherin clusters and the actin
cytoskeleton. The biological necessity of AJ proteins has been

  

Source: Anderson, Richard - Molecular and Cellular Pharmacology Training Program & Department of Pharmacology, University of Wisconsin at Madison

 

Collections: Biology and Medicine