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news & views nature genetics volume 24 april 2000 333
 

Summary: news & views
nature genetics volume 24 april 2000 333
any LINE transcript in trans, LINEs with
defects in ORF1 or ORF2 (or both) could
propagate as parasites of healthy LINEs,
much as SINEs are thought to do, or per-
haps like defective interfering particles do
during viral infections. Mutant LINEs
would accumulate at the expense of
healthy LINEs, and the LINE lineage
might head for extinction.
Remarkably, LINEs may be saved from
extinction by purifying selection. The data
of Esnault et al.6 indicate that the LINE
retroposition machinery does not act
preferentially on LINE mRNAs (as might
have been expected), but rather, on the
particular mRNA that encodes the reverse
transcriptase. This cis effect implies that
LINEs encoding functional ORF1 and

  

Source: Akabas, Myles - Department of Physiology and Biophysics, Albert Einstein College of Medicine, Yeshiva University

 

Collections: Biology and Medicine