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Water and solute permeability of rat lung caveolae: high permeabilities explained by acyl chain unsaturation
 

Summary: Water and solute permeability of rat lung caveolae:
high permeabilities explained by acyl chain unsaturation
Warren G. Hill, Eyad Almasri, W. Giovanni Ruiz, Gerard Apodaca, and Mark L. Zeidel
Laboratory of Epithelial Cell Biology, Renal-Electrolyte Division,
Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania
Submitted 7 February 2005; accepted in final form 15 February 2005
Hill, Warren G., Eyad Almasri, W. Giovanni Ruiz, Gerard
Apodaca, and Mark L. Zeidel. Water and solute permeability of rat
lung caveolae: high permeabilities explained by acyl chain unsatura-
tion. Am J Physiol Cell Physiol 289: C33C41, 2005. First published
February 23, 2005; doi:10.1152/ajpcell.00046.2005.--Caveolae are
invaginated membrane structures with high levels of cholesterol,
sphingomyelin, and caveolin protein that are predicted to exist as
liquid-ordered domains with low water permeability. We isolated a
caveolae-enriched membrane fraction without detergents from rat
lung and characterized its permeability properties to nonelectrolytes
and protons. Membrane permeability to water was 2.85 0.41
10 3
cm/s, a value 510 times higher than expected based on
comparisons with other cholesterol and sphingolipid-enriched mem-

  

Source: Apodaca, Gerard - Departments of Medicine & Cell Biology and Physiology, University of Pittsburgh

 

Collections: Biology and Medicine