Summary: Network motifs in integrated cellular
networks of transcription­regulation and
protein­protein interaction
Esti Yeger-Lotem*
, Shmuel Sattath*, Nadav Kashtan
, Shalev Itzkovitz
, Ron Milo
, Ron Y. Pinter
, Uri Alon
,
and Hanah Margalit*§
*Department of Molecular Genetics and Biotechnology, Faculty of Medicine, Hebrew University, Jerusalem 91120, Israel; Department of Computer Science,
Technion, Haifa 32000, Israel; and Departments of Molecular Cell Biology and Physics of Complex Systems, Weizmann Institute of Science,
Rehovot 76100, Israel
Edited by Nancy J. Kopell, Boston University, Boston, MA, and approved February 20, 2004 (received for review October 20, 2003)
Genes and proteins generate molecular circuitry that enables the
cell to process information and respond to stimuli. A major chal-
lenge is to identify characteristic patterns in this network of
interactions that may shed light on basic cellular mechanisms.
Previous studies have analyzed aspects of this network, concen-

Source: Alon, Uri - Departments of Molecular Cell Biology & Physics of Complex Systems, Weizmann Institute of Science
Pinter, Ron - Department of Computer Science, Technion, Israel Institute of Technology

Collections: Biology and Medicine; Computer Technologies and Information Sciences