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EMBO Member's Review Chromatin density and splicing destiny: on the

Summary: EMBO Member's Review
Chromatin density and splicing destiny: on the
cross-talk between chromatin structure and
Schraga Schwartz and Gil Ast*
Department of Human Molecular Genetics and Biochemistry, Sackler
Faculty of Medicine, Tel-Aviv University, Ramat Aviv, Israel
How are short exonic sequences recognized within the vast
intronic oceans in which they reside? Despite decades of
research, this remains one of the most fundamental, yet
enigmatic, questions in the field of pre-mRNA splicing
research. For many years, studies aiming to shed light on
this process were focused at the RNA level, characterizing
the manner by which splicing factors and auxiliary proteins
interact with splicing signals, thereby enabling, facilitating
and regulating splicing. However, we increasingly under-
stand that splicing is not an isolated process; rather it
occurs co-transcriptionally and is presumably also regu-
lated by transcription-related processes. In fact, studies by
our group and others over the past year suggest that DNA


Source: Ast, Gil - Department of Molecular Genetics and Biochemistry, Tel Aviv University


Collections: Biology and Medicine