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Summary: The Journal of Neuroscience, August 1992, 72(8): 2901-2917
Synaptic Interactions between GABA-immunoreactive Profiles and
the Terminals of Functionally Defined Myelinated
Nociceptors in the Monkey and Cat Spinal Cord
Francisco J. Alvarez, Anahid M. Kavookjian, and Alan Ft. hight
Department of Physiology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina.27599
This study analyzes the synaptic interactions between the
central terminals of A6 high threshold mechanoreceptors (A6
HTMs) and GABA-immunoreactive profiles. A6 HTM primary
afferents from three monkeys and one cat were electro-
physiologically identified and intracellularly labeled with HRP,
and their terminal arborizations in laminae I and II of the
sacrocaudal spinal cord were studied at the ultrastructural
level. GABA-immunoreactive profiles in relation to Ab HTM
terminals were demonstrated using postembedding colloidal
gold techniques.
Monkey A6 HTM terminals (n = 131) usually constituted
the central element of synaptic glomeruli; they established
large asymmetric synaptic contacts with 1-13 dendrites
(modal value 2-4) and were surrounded by O-6 peripheral
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