Advanced Search

Browse by Discipline

Scientific Societies

E-print Alerts

Add E-prints

E-print Network

  Advanced Search  

WiskottAldrich syndrome protein (WASP) and N-WASP are critical for T cell development

Summary: Wiskott­Aldrich syndrome protein (WASP) and
N-WASP are critical for T cell development
Vinicius Cotta-de-Almeida*§
, Lisa Westerberg*
, Michel H. Maillard*
, Dilek Onaldi*
, Heather Wachtel*¶
Parool Meelu*
, Ung-il Chung , Ramnik Xavier*¶
, Frederick W. Alt**§§
, and Scott B. Snapper*§§
*Gastrointestinal Unit, Center for the Study of Inflammatory Bowel Disease, Endocrine Unit, ¶Department of Molecular Biology, Massachusetts General
Hospital, Boston, MA 02114; **Howard Hughes Medical Institute, Children's Hospital, Boston, MA 02115; Center for Blood Research, Boston, MA 02115;
Departments of Genetics and Medicine, Harvard Medical School, Boston, MA 02115; and §Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, RJ,
21045-900, Brazil
Contributed by Frederick W. Alt, July 27, 2007 (sent for review January 9, 2007)
Although T cell dysfunction and lymphopenia are key features of
immunodeficient patients with the Wiskott­Aldrich syndrome and
Wiskott­Aldrich syndrome protein (WASP)-deficient mice, T cell


Source: Alt,, Frederick - Immune Disease Institute, Harvard University


Collections: Biology and Medicine