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Brief Communication 223 NURD-complex genes antagonise Ras-induced vulval development
 

Summary: Brief Communication 223
NURD-complex genes antagonise Ras-induced vulval development
in Caenorhabditis elegans
Florence Solari and Julie Ahringer
Chromatin-modifying complexes are important for
transcriptional control, but their roles in the regulation
of development are poorly understood. Here, we show
that components of the nucleosome remodelling and
histone deacetylase (NURD) complex [15] antagonise
vulval development, which is induced by the Ras signal
transduction pathway. In three of the six equivalent
vulval precursor cells, the Ras pathway is active, leading
to the production of vulval fates [6]; in the remaining
three, the Ras pathway is inhibited and vulval fates
repressed. Inhibition of Ras signaling occurs in part
through the action of the synthetic multivulval (synMuv)
genes, which comprise two functionally redundant
pathways (synMuvA and synMuvB) [7]. We found that
five Caenorhabditis elegans members of the NURD
chromatin remodelling complex inhibit vulval

  

Source: Ahringe, Julie - Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge

 

Collections: Biology and Medicine