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NEUROBIOLOGY OF LEARNING AND MEMORY 64, 191194 (1995) RAPID COMMUNICATION
 

Summary: NEUROBIOLOGY OF LEARNING AND MEMORY 64, 191194 (1995)
RAPID COMMUNICATION
Scopolamine Selectively Disrupts the Acquisition of
Contextual Fear Conditioning in Rats
STEPHAN G. ANAGNOSTARAS, STEPHEN MAREN, AND MICHAEL S. FANSELOW
1
Department of Psychology and Brain Research Institute, The University of California, Los Angeles, 405 Hilgard Avenue,
Los Angeles, California 90095-1563
Recent studies indicate that the hippocampus has
Muscarinic cholinergic antagonism produces learning an important role in Pavlovian fear conditioning.
and memory deficits in a variety of hippocampal-depen- During fear conditioning, a conditional stimulus (of-
dent tasks. Hippocampal lesions produce both acquisition ten a tone) is paired with an aversive unconditional
deficits and retrograde amnesia for contextual fear condi-
stimulus (usually an electrical shock) in a novel con-
tioning, but do not impact fear conditioning to discrete
text. With repeated pairings, the animal learns tocues. In order to examine the effects of muscarinic antago-
fear both the tone and the training context. Hippo-nism in this paradigm, rats were given scopolamine (1
campal lesions produce an acquisition deficit (Phil-mg/kg) either before or for 3 days after a Pavlovian fear-
lips & LeDoux, 1992) and a time-limited retrogradeconditioning session in which tones were paired with aver-
amnesia that is selective for contextual fear (Kim &sive footshocks. Fear to the context and the tone was as-

  

Source: Anagnostaras, Stephan - Neurosciences Program & Department of Psychology, University of California at San Diego

 

Collections: Biology and Medicine