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Copyright 2001 by the Genetics Society of America Regions of Lower Crossing Over Harbor More Rare Variants in
 

Summary: Copyright 2001 by the Genetics Society of America
Regions of Lower Crossing Over Harbor More Rare Variants in
African Populations of Drosophila melanogaster
Peter Andolfatto* and Molly Przeworski
*Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh, EH9 3JT, United Kingdom and

Department of Statistics, Oxford University, Oxford, OX1 3TG, United Kingdom
Manuscript received November 7, 2000
Accepted for publication February 3, 2001
ABSTRACT
A correlation between diversity levels and rates of recombination is predicted both by models of positive
selection, such as hitchhiking associated with the rapid fixation of advantageous mutations, and by models
of purifying selection against strongly deleterious mutations (commonly referred to as "background selec-
tion"). With parameter values appropriate for Drosophila populations, only the first class of models predicts
a marked skew in the frequency spectrum of linked neutral variants, relative to a neutral model. Here,
we consider 29 loci scattered throughout the Drosophila melanogaster genome. We show that, in African
populations, a summary of the frequency spectrum of polymorphic mutations is positively correlated with
the meiotic rate of crossing over. This pattern is demonstrated to be unlikely under a model of background
selection. Models of weakly deleterious selection are not expected to produce both the observed correlation
and the extent to which nucleotide diversity is reduced in regions of low (but nonzero) recombination.

  

Source: Andolfatto, Peter - Department of Ecology and Evolutionary Biology, Princeton University

 

Collections: Biology and Medicine