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Brain Morphological Signatures for Chronic Pain Marwan N. Baliki1
 

Summary: Brain Morphological Signatures for Chronic Pain
Marwan N. Baliki1
, Thomas J. Schnitzer2
, William R. Bauer3
, A. Vania Apkarian1,4,5
*
1 Department of Physiology, Northwestern University, Chicago, Illinois, United States of America, 2 Department of Physical Medicine and Rehabilitation, Northwestern
University, Chicago, Illinois, United States of America, 3 Department of Neuroscience, University of Toledo, Toledo, Ohio, United States of America, 4 Department of
Anesthesia, Feinberg School of Medicine, Chicago, Illinois, United States of America, 5 Department of Surgery, Feinberg School of Medicine, Chicago, Illinois, United States
of America
Abstract
Chronic pain can be understood not only as an altered functional state, but also as a consequence of neuronal plasticity.
Here we use in vivo structural MRI to compare global, local, and architectural changes in gray matter properties in patients
suffering from chronic back pain (CBP), complex regional pain syndrome (CRPS) and knee osteoarthritis (OA), relative to
healthy controls. We find that different chronic pain types exhibit unique anatomical `brain signatures'. Only the CBP group
showed altered whole-brain gray matter volume, while regional gray matter density was distinct for each group. Voxel-wise
comparison of gray matter density showed that the impact on the extent of chronicity of pain was localized to a common
set of regions across all conditions. When gray matter density was examined for large regions approximating Brodmann
areas, it exhibited unique large-scale distributed networks for each group. We derived a barcode, summarized by a single
index of within-subject co-variation of gray matter density, which enabled classification of individual brains to their

  

Source: Apkarian, A. Vania - Department of Physiology, Northwestern University

 

Collections: Biology and Medicine